What side effect is associated with the use of Fluoxetine/Prozac in neonates?

Fluoxetine, commonly known as Prozac, is a selective serotonin reuptake inhibitor (SSRI) used to treat various mood disorders and is occasionally prescribed during pregnancy. When SSRIs like fluoxetine are used in pregnant individuals, there is a potential for side effects in neonates, particularly if the medication is taken in the latter stages of pregnancy.

Crying, irritability, and gastro-intestinal (GI) issues are known effects linked to in utero exposure to SSRIs. Neonates can exhibit withdrawal-like symptoms or adaptation issues, which may manifest as excessive crying, heightened irritability, or difficulties with feeding, such as vomiting or diarrhea. These symptoms generally arise due to the neonate's adjustment to the absence of the medication after birth, as they may have developed some dependency during gestation. The gastrointestinal issues can include symptoms like feeding difficulties or gastrointestinal distress, contributing to irritability and discomfort.

Understanding these potential side effects is crucial for healthcare professionals when prescribing SSRIs to pregnant individuals, as awareness can lead to better monitoring and support for both the mother and the newborn following delivery.