What evidence exists regarding antidepressants and the risk of miscarriage?

The assertion that stopping SSRIs (selective serotonin reuptake inhibitors) before conception elevates miscarriage risk is supported by various studies indicating that abruptly discontinuing these medications can lead to adverse changes in maternal mental health. Specifically, untreated depression or anxiety during the perinatal period can contribute to an increased risk of miscarriage. It is important to consider that SSRIs, when taken consistently and appropriately, may help to stabilize a woman’s mental health, thereby potentially reducing the risk associated with fluctuating mood disorders.

Research has shown that maintaining mental health stability through the use of SSRIs can be critical during the early stages of pregnancy. Discontinuing these medications can precipitate a decline in mental health, which in turn may have negative implications for both the mother and the developing fetus, contributing to stress and other factors detrimental to pregnancy outcomes.

The other choices do not align with current evidence. The idea that continuing SSRIs has no effect on miscarriage risk does not acknowledge the complexity of how maternal mental health can impact pregnancy. The concept that SSRIs prevent miscarriage is not supported, as these medications are not proven to directly prevent miscarriages but may help maintain overall maternal health. Lastly, the statement that there is no evidence related to SSRIs and miscarriage contradicts existing