What complication is noted with the use of Prazosin during pregnancy?

The use of Prazosin during pregnancy has been associated with a higher complication rate after the third trimester due to potential effects on maternal blood pressure and cardiovascular responses. Prazosin is primarily an alpha-1 adrenergic antagonist used to treat hypertension and has been investigated for its effects on conditions like post-traumatic stress disorder (PTSD), which can present during the perinatal period. In the later stages of pregnancy, when the body is preparing for labor and delivery, any medication that impacts vascular resistance and blood pressure regulation can lead to increased risks for both the mother and fetus, including complications related to labor and delivery.

The other options represent different potential complications that are not specifically associated with Prazosin. For example, while low birth weight can result from various maternal conditions and medications, Prazosin is not specifically linked to this outcome. Fetal alcohol syndrome is related to alcohol consumption during pregnancy, not Prazosin. Respiratory distress may occur in neonates for various reasons, but it's not a recognized complication of Prazosin use. Therefore, the association of higher complication rates in the third trimester stands out as the most pertinent concern when considering the use of Prazosin during pregnancy.